Ứng dụng

Metal-organic compounds are commonly used in organic chemistry, for example as Grignard reagents or as strong bases (e.g., butyl lithium compounds). The knowledge of the exact content of reactive species allows to better plan the required amounts for reactions preventing the waste of material or too low yields. This Application Note describes the analysis of metal organics by thermometric titration using 2-butanol as titrant. Due to the strongly exothermic nature of the reaction between 2-butanol with metal-organic compounds, a fast and quantitative analysis of these substances is possible.

The water content of organic peroxides is determined according to Karl Fischer using two-component reagents. To prevent any unwanted side reactions, the determinations are carried out at -20 °C.

This Process Application Note presents a method to closely monitor low levels of moisture in propylene oxide safely and reliably by using a single explosion-proof inline process analyzer.

Determination of hexafluorophosphate in an ionic liquid BMIHFP (1-butyl-3-methylimidazolium hexafluorophosphate, >97%) using anion chromatography with conductivity detection after chemical suppression.

Analysis of sodium hydrogen carbonate (also known as sodium bicarbonate) for anionic contaminants is critical due the large amount of CO2 formed during suppression. Even applying sequential suppression does not completely remove the interferences due to the carbonate peak. The introduction of Inline Neutralization applying the Sample Preparation Module (SPM) with subsequent CO2 removal with the MCS (Metrohm CO2 Suppressor) prior to the injection solves the problem. After this pretreatment, the sequentially suppressed sample is analyzed without issues.

E-book này giải thích cách quang phổ Raman và quang phổ cận hồng ngoại (NIR) cho phép phân tích polymer nhanh chóng, không phá hủy, đảm bảo chất lượng cao đồng thời giảm chi phí và lãng phí.

The automated combination of pyrolysis and subsequent ion chromatography (Combustion IC) permits the parallel detection of halogens and sulfur in all flammable solid and liquid matrices. The method is captivating, not only because of its outstanding precision and trueness, but also because of the high sample throughput.

Underestimation of quality control (QC) processes is one of the major factors leading to internal and external product failure, which have been reported to cause a loss of turnover between 10–30%. As a result, many different norms are put in place to support manufacturers with their QC process. However, time to result and the associated costs for chemicals can be quite excessive, leading many companies to implement near-infrared spectroscopy (NIRS) in their QC process. This paper illustrates the potential of NIRS and displays cost saving potentials up to 90%.

Ion measurement can be conducted in several different ways, e.g., ion chromatography (IC), inductively coupled plasma optical emission spectrometry (ICP-OES), or atom absorption spectroscopy (AAS). Each of these are well-established, widely used methods in analytical laboratories. However, the initial costs are relatively high. In contrast, ion measurement by the use of an ion-selective electrode (ISE) is a promising alternative to these costly techniques. This White Paper explains the challenges which may be encountered when applying standard addition or direct measurement, and how to overcome them in order for analysts to gain more confidence with this type of analysis.

This white paper summarizes the steps involved in converting an existing manual titration procedure to semi-automated or automated titration procedures. It discusses topics such as selecting the right electrode and titration mode. For a better understanding, the discussion topics are illustrated with three examples.

Ion chromatography mass spectrometry (IC-MS) is a powerful tool that can handle many challenging analytical tasks which cannot be performed adequately by IC alone. IC-MS is a robust, sensitive, and selective technique used for the determination of polar contaminants like inorganic anions, organic acids, haloacetic acids, oxyhalides, or alkali and alkaline earth metals. After separation of the sample components via IC, mass selective detection guarantees peak identity with low detection limits. The inclusion of automated Metrohm Inline Sample Preparation (MISP) allows not only water samples, but also chemicals, organic solvents, or post-explosion residues to be readily analyzed without need for extensive manual laboratory work. This White Paper explains the benefits of IC-MS over IC in certain cases, the hyphenation of IC and different MS systems, as well as related norms and standards.

Mục đích của việc thẩm định quy trình phân tích là để chứng minh rằng nó phù hợp với mục đích sử dụng riêng. Các khuyến cáo về thẩm định phương pháp phân tích có thể được tìm thấy trong ICH Guidance Q2(R1) Validation of Analytical Procedures: Text and Methodology [1] và trong USP General Chapter <1225> Validation of Compendial Procedures. Mục đích của tài liệu này là để cung cấp một vài khuyến cáo về thẩm định phương pháp chuẩn độ.

Trong White Paper này, bạn sẽ tìm hiểu về MIRA XTR DS – hệ thống Raman cầm tay nhỏ nhất, thông minh nhất, linh hoạt nhất với các thư viện lớn nhất hiện có trên thị trường! MIRA XTR DS có tất cả các lợi ích định tính Raman 785 nm: kích thước nhỏ gọn, công suất laser thấp, bảo quản mẫu, tuổi thọ pin dài... giờ đây có khả năng loại bỏ huỳnh quang. Ngoài ra, độ nhạy và độ phân giải được cải thiện so với các hệ thống 1064 nm. Điều này mở ra những khả năng mới cho Raman 785 nm, bao gồm các vật liệu có màu đậm, tá dược thông thường, vật liệu bất hợp pháp, v.v.